39. Animal Welfare

Which of these was originally the Animal Care Panel (ACP)?

AALAS, 1950

ACLAM, 1958

AAALAC, 1965

AALAS, 1950

5 founding fathers for ACP/ AALAS?

Drs Nathan Brewer, Elihu Bond, Robert Flynn, Bennett Cohen and Robert Schroeder

The harm: benefit analysis of a proposed study by an IACUC is an example of a ___________ calculation in which the moral significance of humans is usually considered greater than that of animals.

utilitarian-

Animals should not be caused to suffer unnecessarily and should be used in ways that produce significant and tangible benefits

Humans are considered to have greater moral significance in these calculations

Dominant, mainstream approach

The utilization of Corneal opacity and permeability test (ICE) and

Cytosensor mircrophysiometer instead of Draize test is an example of which R?

Replacement

2 multiple choice options

The utilization of LAL Test = Limulus Amebocyte Lysate test and Monocyte activation testing (MAT) instead of rabbit pyrogen test is an example of which R?

Replacement

2 multiple choice options

Inbred rats/mice 🡪 reduces confounders, ultimately reducing the # of animals needed for research

Longitudinal imaging 🡪 allows non-invasive collection of data over time, rather than euthanizing animals at multiple time-points to follow progression of a disease

are all examples of which R?

Reduction

2 multiple choice options

Microsampling for blood collection

Telemetry implant for subsequently less stressful data collection

Imaging

Use of analgesia and supportive care

Implementation of humane end points

Environmental enrichment

are all examples of which R?

Refinement

2 multiple choice options