Non-sterile Compounding Exam Study Guide

What is the purpose of the USP Chapter <795>?

Guidelines for nonsterile compounding in pharmacies.

Where should the liquid be read when using a graduated cylinder?

Bottom of the meniscus

How long should you wash your hands before compounding?

At least 30 seconds

A refrigerated aqueous solution or suspension always has a beyond-use-date of what?

14 days

Name the capsule sizes smallest to largest

000

00

0

1

2

3

4

5

What is contained in an SDS?

Contains important information about the hazards, handling, storage, and emergency procedures for a specific chemical or product. It includes details about the composition, physical properties, first aid measures, and safety precautions.

The master formulation record is also known as what?

Standard Recipe

What is the compounding record?

Patient specific version of the master formulation with the specific amount of drug needed for prescription

What does Blending mean?

The combination of 2 substances (various methods)

What does Trituration mean?

The process of rubbing or grinding particles to a finer size (No fluids involved)

What does Communition mean?

Process of physical reduction of a substance to fine particle size (various methods)

What does Sifting mean?

Blending or combing 2 substances using a wire mesh sieve

What does Tumbling mean?

Placing substances into a container and rotating the container to mix them

What does Spatulation mean?

Mixing a substance using a spatula

What does Levigation mean?

A technique used to make particle sizes smaller while making an ointment

What does Pulverization mean?

The process of applying an external force to a (solid) material of a certain size mixed with another ingredient that can dissolve the ingredient (like sugar and water)

{same thing as trituration just fluid is added}

You need to prepare 150 ml of dextrose 5.5% using dextrose 2.5% dextrose 25%. How many ml of each will be needed?

20 ml of 25% dextrose

130 ml of 2.5% dextrose

You receive an order for 120 grams of zinc oxide ointment. Use the following formula to find out how many grams of Zinc Oxide will you need to use to make the 120 grams in the prescription.

STARCH: 70 grams

ZINC OXIDE: 50 grams

PETROLEUM: 150 grams

22.2 grams

You need to prepare 200 ml of HCTZ 25mg/ml. How many tablets of HCTZ 25 mg tablets will you need?

8 tablets

(dividing the total required dose by the strength of each tablet, you can determine the number of tablets needed.)

A prescription calls for 300 ml of dextrose 7% from D5W and D20W. How much of the D5W will you use?

260 ml of D5W

You are to prepare an order for 60 grams of ABC cream using the following formula listing the ingredients and their percentages for the compound. How much coal tar is needed for this order?

COAL TAR 2%

CC POWDER 10%

LANOLIN 60%

CALCIUM MANGANATE 7%

PETROLEUM 21%

1.2 grams

(add all the percentages together: 2+10+60+7+21=100

Then ratio proportion:

2/10 X/60

60×2=120

120/100 = 1.2

You need to prepare 400 ml of an Iodine solution for a patient. The recipe is below. How much of each ingredient will you use to fill the 400 ml?

IODINE 30 grams

SODIUM IODINE 24 grams

PURIFIED WATER QSAD 100 ml

IODINE 120 grams

SODIUM IODINE 96 grams

PURIFIED WATER 400 ml

( the quantity you need / the amount the recipe is for: 400/100= 4

then take each ingredient in the recipe and multiply by the 4

30×4=120

24×4=96

100×4=400

Determine how much glycerin ingredient you will need to make 150 suppositories using the following formula

GLYCERIN 180 g

SODIUM STEARATE 17.8 g

PURIFIED WATER 9 ml

Formula makes #100 glycerin suppositories

270 g of glycerin

(the quantity you need / the amount the recipe is for: 150/100=1.5

then take ingredient in the recipe and multiply by the 1.5

180×1.5=270

A prescription is written for Tylenol cream 10%. How much acetaminophen powder is needed to prepare 60 grams of this compound?

6 grams

(ratio proportion:

10/100 X/60

60×10=600

600/100=6)

If there are 300 mg in a 5 ml dose, what is the percentage strength?

6%

(we can use the amount of medication (300 mg) and the volume of the dose (5 ml).

First, we need to convert the volume to milligrams by multiplying it by 1,000:

5 ml x 1,000 = 5,000 mg

Then, we can calculate the percentage strength by dividing the amount of medication (300 mg) by the total volume of the dose (5,000 mg) and multiplying by 100:

(300 mg / 5,000 mg) x 100 = 6%

If there are 40 g of dextrose in a 1 L IV bag, what is the percentage strength?

4%

(we can use the amount of dextrose (40 g) and the volume of the IV bag (1 L).

First, we need to convert the volume to milliliters by multiplying it by 1,000:

1 L x 1,000 = 1,000 mL

Then, we can calculate the percentage strength by dividing the amount of dextrose (40 g) by the total volume of the IV bag (1,000 mL) and multiplying by 100:

(40 g / 1,000 mL) x 100 = 4%)

How many grams of sodium chloride are in 2 L of NS?

18 grams

(If you have a 0.9% Sodium Chloride (NS) solution, it means that there are 0.9 grams of sodium chloride in every 100 mL of solution.

To calculate the amount of sodium chloride in 2 L of NS, we can use the following steps:

1. Convert 2 L to milliliters by multiplying by 1,000:

2 L x 1,000 = 2,000 mL

2. Calculate the amount of sodium chloride in 2,000 mL of NS:

(0.9 g / 100 mL) x 2,000 mL = 18 grams)

The act of filling capsules in nonsterile compounding is commonly known as the _____ method.

scoop

Why is it important to be sure that all of the supplies are clean prior to compounding?

To prevent contamination and ensure the safety and effectiveness of the compounded medication.

The most appropriate size syringe for a 4.5 ml dose is what size of syringe?

5 ml syringe

What does Excipient mean?

Inactive ingredient

(Flavoring, compounding base, alcohol, stabilizers)

What does Troche mean?

A dissolvable dosage form also known as a lozenge

What is the first step of the compounding process?

Receive medication order/prescription

What is the second step of the compounding process?

Enter Rx into patient profile

What is the third step of the compounding process?

Make or find a master formulation record

What is the fourth step of the compounding process?

Make a specific compounding record

What is the fifth step of the compounding process?

Pharmacist or technician prepares the area and themselves

What is the sixth step of the compounding process?

Gather required equipment and ingredients

Where is the compounding record stored?

with the prescription