HEMATOLOGY PRE-TEST

Gauge of the needle indicating the largest bore is:

16 gauge

19 gauge

21 gauge

23 gauge

16 gauge

What is the anticoagulant of choice for the osmotic fragility test?

Heparin

Hemoglobin migration pattern on cellulose acetate from point of application to anode is

C and A2 < S < F < A

Insufficient centrifugation will result in

false increase in hematocrit value

Variation in red cell size observed on the

peripheral smear is described as:

Anisocytosis

Which of the following is the preferable site for

bone marrow aspiration and biopsy in an adult?

Iliac crest

Mean cell volume (MCV) is calculated using the

following formula

(Hct ÷ RBC) × 10

What is the appropriate reagent for the reticulocyte count?

New methylene blue

Which of the following is not an appropriate safety practice?

Disposing of needles in biohazard, puncture-proof containers

Frequent handwashing

Sterilizing lancets for reuse

Keeping food out of the same areas as specimens

Sterilizing lancets for reuse

When the coagulation of fresh whole blood is prevented through the use of an anticoagulant, the straw-colored fluid that can be separated from the cellular elements is

plasma

The bevel of the needle should be held _____ in the performance of a venipuncture

upward

Poor blood smears can be caused by

a delay in preparing the smear once the drop of blood has been placed on the slide

drop of blood that is too large or too small

holding the pusher slide at the wrong angle and poor drying conditions

all of the above

all of the above

Glycogen is a

carbohydrate

Phagocytosis is

a type of endocytosis

the engulfment of fluid molecules

the engulfment of particulate matter

Both A and C

Both A and C

The first inherited hematologic disorder to be diagnosed using molecular biologic assay was

sickle cell anemia

The normal sequence of blood cell development is

yolk sac—liver and spleen—red bone marrow

The maturational sequence(s) of the erythrocyte is (are)

rubriblast—prorubricyte—rubricyte—metarubricyte—reticulocyte—mature erythrocyte

prorubricyte—rubricyte—metarubricyte—reticulocyte—mature erythrocyte

pronormoblast—basophilic normoblast—polychromatophilic normoblast—orthochromic normoblast—reticulocyte—mature erythrocyte

both A and C

both A and C

A 7-mL EDTA tube is received in the laboratory containing only 2 mL of blood. If the laboratory is using manual techniques, which of the following tests will most likely be erroneous?

Hematocrit

A decreased OFT would be associated with which of the following conditions?

Sickle cell anemia

What effect would using a buffer at pH 6.0 have on Wright’s-stained smear?

red cell would be stained too pink

All of the following may influence the ESR, except:

blood drawn into a sodium citrate tube

anisocytosis, poikilocytosis

plasma proteins

calibre of the tube

blood drawn into a sodium citrate tube

Which ratio of anticoagulant to blood is correct for coagulation procedures?

1:9

The following are compounds formed in the synthesis of heme:

1. coproporphyrinogen

3. uroporphyrinogen

2. porphobilinogen

4. protoporphyrinogen

Which of the following responses lists these compounds in the order in which they are formed?

2,3,1,4

Which of the following is most likely to be seen in lead poisoning?

basophilic stippling

Normal platelets have a circulating life span of approximately:

10 days

Coagulation factors affected by coumarin drugs are:

II, VII, IX, and X

Which of the following is NOT a contact factor?

Stable factor

The most concentrated coagulation factor in the blood is:

Fibrinogen

When making a blood film using the spreader slide technique, a thinner film can be obtained by:

Spreading the blood at lower speed

The largest hematopoietic cells in normal bone marrow are:

Megakaryocytes

Which of the following depicts the structure of the hemoglobin molecule?

Four heme groups, four globin chains

Ecarin clotting time may be used to monitor:

Hirudin therapy

What staining method is used most frequently to

stain and manually count reticulocytes?

Supravital staining

What is the major type of leukocyte seen in

the peripheral smear of a patient with aplastic

anemia?

Lymphocyte

What is the normal WBC differential lymphocyte

percentage (range) in the adult population?

20%–44%

Which of the following organs is responsible for

the “pitting process” for RBCs?

Spleen

“Bite cells” are usually seen in patients with:

G6PD deficiency

Which morphological classification is

characteristic of megaloblastic anemia?

Macrocytic, normochromic

Auer rods may be seen in all of the following

except:

Acute myelomonocytic leukemia (M4)

Acute lymphoblastic leukemia

Acute myeloid leukemia without maturation (M1)

Acute promyelocytic leukemia (M3)

Acute lymphoblastic leukemia

Which type of anemia is usually present in a

patient with acute leukemia?

Normocytic, normochromic

In which age group does acute lymphoblastic

leukemia occur with the highest frequency?

1–15 years

Which of the following is a characteristic of

Auer rods?

They are composed of azurophilic granules

They stain periodic acid–Schiff (PAS) positive

They are predominantly seen in chronic myelogenous leukemia (CML)

They are nonspecific esterase positive

They are composed of azurophilic granules

In myeloid cells, the stain that selectively identifies

phospholipid in the membranes of both primary

and secondary granules is

Sudan Black B stain

The WHO classification requires what percentage

for the blast count in the blood or bone marrow

for the diagnosis of AML?

At least 20%

In myelofibrosis, the characteristic abnormal red

blood cell morphology is that of:

Teardrop cells

What is the average life span of a normal

red blood cell?

120 days

The major storage form of iron is

Ferritin

Which of the following factors is not

associated with variations in the total

white blood cell count?

Sex

What is the term for cell movement

through blood vessels to a tissue site?

Diapedesis

Vasodilation and bronchoconstriction are

the result of degranulation by which of the

following blood cells?

Basophils