Atherosclerosis and CAD (Week 6 Perfusion)

Medications: Statins

• Inhibit synthesis of cholesterol in liver

• Liver removes more LDL cholesterol from blood

• Slight increase in HDL cholesterol

• PTT may increase with combined use of Warfarin

• Monitor LFTs and for rhabdomyolysis (muscle pain, dark urine)

Medication: Fibric Acid Derivatives (Fenofibrate, Gemfibrozil)

• Aids to remove VLDL (very LDL)

• Lowers triglycerides, increases HDL levels

• Monitor for s/s bleeding with combined use of Warfarin

• Increased risk of rhabdomyolysis and elevated liver enzymes when combined with statin

Medication: Antiplatelet

Aspirin: Decreases platelet aggregation (clumping), minor inhibition of vasoconstriction. Watch for GI upset, GI ulceration, tinnitus (ringing in the ears, a sign of aspirin toxicity)

What is the recommended level of physical activity for cardiovascular health?

Desired activity level = 150 minutes per week (30-minute sessions 5 days a week) of brisk walking, biking, swimming

How does atherosclerosis contribute to hypertension?

It narrows major arteries, increasing vascular resistance

What organ damage can result from atherosclerosis-induced ischemia?

• Blindness

• Renal failure

• Diabetic foot amputations