703 Lecture: Week 9-10

Lecture: Week 9-10 - Cellular fate processes part 2

What are the 2 types of Cell Death

Necrosis - Caused by an accidental injury or environmental factors. The death of most or all of the cells in an organ or tissue due to disease, injury, or failure of the blood supply
Apoptosis - Programmed Cell Death

What are the 3 stages of necrosis

Swelling - Small bleb become larger through swelling of endoplamic reticulum and mitochondria
Breakdown - Cell contents leak out (Plasma Membrane, Organelles, etc)
Imflammatory Response - sends macrophages to process

What are the 3 stages of Apoptosis

Signalling - Cells are signalled via a trigger (DNA damage, cell gets old, etc). Enzyme copsases is created and initialized cell death
Fragmentation - Shrinking of the nucleus and digests other organelles of the body including mitochondria and EPR.
Phagocytosis - Eliminate and ingest pathogens and deal cells

List the difference between the necrosis and apoptosis process

Necrosis is uncontrolled and insignaled while apoptosis is the opposite being controlled and activated by a trigger
Leakage of cellular content in necrosis while cytoskeleton intact in apoptosis

What is the equation that defines apoptosis?